Cargando…

Zein-Stabilized Nanospheres as Nanocarriers for Boosting the Aphrodisiac Activity of Icariin: Response Surface Optimization and In Vivo Assessment

Icariin (ICA), a main active compound of the Epimedium genus, is used as an aphrodisiac in traditional Chinese herbal medicine. Despite its therapeutic efficacy, ICA displays reduced oral absorption, and therefore, low bioavailability hindered its clinical application. Implementing nanotechnology in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asfour, Hani Z., Alhakamy, Nabil A., Fahmy, Usama A., Ahmed, Osama A. A., Rizg, Waleed Y., Felimban, Raed I., Abdel-Naim, Ashraf B., Abourehab, Mohammad A. S., Mansouri, Rasha A., Omar, Ulfat M., Badr-Eldin, Shaimaa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227839/ https://www.ncbi.nlm.nih.gov/pubmed/35745852 http://dx.doi.org/10.3390/pharmaceutics14061279

Ejemplares similares

Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Piceatannol-Loaded Bilosome-Stabilized Zein Protein Exhibits Enhanced Cytostatic and Apoptotic Activities in Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells
por: Fahmy, Usama A., et al.
Publicado: (2020)

Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives
por: Tan, Hui-Li, et al.
Publicado: (2016)

Development, Optimization and Evaluation of 2-Methoxy-Estradiol Loaded Nanocarrier for Prostate Cancer
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
por: Badr-Eldin, Shaimaa M., et al.
Publicado: (2021)

Fabrication and characterization of DNA-loaded zein nanospheres
por: Regier, Mary C, et al.
Publicado: (2012)

Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment
por: Aldawsari, Hibah M., et al.
Publicado: (2021)

Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2019)

Optimized zein nanospheres for improved oral bioavailability of atorvastatin
por: Hashem, Fahima M, et al.
Publicado: (2015)

Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer
por: Alfaleh, Mohamed A., et al.
Publicado: (2022)

Phyto-Phospholipid Conjugated Scorpion Venom Nanovesicles as Promising Carrier That Improves Efficacy of Thymoquinone against Adenocarcinoma Human Alveolar Basal Epithelial Cells
por: Asfour, Hani Z., et al.
Publicado: (2021)

Aphrodisiac Remedies
Publicado: (1929)

Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells
por: Awan, Zuhier A., et al.
Publicado: (2022)

The Encapsulation of Febuxostat into Emulsomes Strongly Enhances the Cytotoxic Potential of the Drug on HCT 116 Colon Cancer Cells
por: Fahmy, Usama A., et al.
Publicado: (2020)

Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation
por: Fahmy, Usama A., et al.
Publicado: (2020)

Aphrodisiacs : from legend to prescription
por: Walton, Alan Hull
Publicado: (1958)

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy
por: Huang, Wenquan, et al.
Publicado: (2023)

Damiana New Aphrodisiac
por: Caldwell, J. J.
Publicado: (1875)

Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats
por: Asfour, Hani Z., et al.
Publicado: (2022)

Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics
por: Ahmed, Osama AA, et al.
Publicado: (2015)

Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route
por: Ahmed, Osama A. A., et al.
Publicado: (2020)

Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability
por: Han, He, et al.
Publicado: (2022)

Enhanced healing efficacy of an optimized gabapentin-melittin nanoconjugate gel-loaded formulation in excised wounds of diabetic rats
por: Asfour, Hani Z., et al.
Publicado: (2022)

Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles
por: Al-Rabia, Mohammed W., et al.
Publicado: (2022)

Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds
por: Alamoudi, Abdullah A., et al.
Publicado: (2022)

The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells
por: Awan, Zuhier A., et al.
Publicado: (2020)

Green Nanoemulsion Stabilized by In Situ Self-Assembled Natural Oil/Native Cyclodextrin Complexes: An Eco-Friendly Approach for Enhancing Anticancer Activity of Costunolide against Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2022)

Scorpion Venom-Functionalized Quercetin Phytosomes for Breast Cancer Management: In Vitro Response Surface Optimization and Anticancer Activity against MCF-7 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Spanlastics as a Potential Platform for Enhancing the Brain Delivery of Flibanserin: In Vitro Response-Surface Optimization and In Vivo Pharmacokinetics Assessment
por: Alharbi, Waleed S., et al.
Publicado: (2022)

Exploring scientifically proven herbal aphrodisiacs
por: Kotta, Sabna, et al.
Publicado: (2013)

A History of Substances Known as Aphrodisiacs
por: Denninger, Henri Stearns
Publicado: (1930)

Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells
por: Fahmy, Usama A., et al.
Publicado: (2022)

Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin
por: Fahmy, Usama A, et al.
Publicado: (2020)

Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Asian herbals and aphrodisiacs used for managing ED
por: Lim, Peter H. C.
Publicado: (2017)

Fingerroot, Boesenbergia rotunda and its Aphrodisiac Activity
por: Ongwisespaiboon, Oranun, et al.
Publicado: (2017)

Thiamethoxam as an inadvertent anti-aphrodisiac in male bees
por: Straub, Lars, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8pshvbpgejkjccqijkd0c2ppvf