Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies

MPI8, a peptidyl aldehyde, is a potent antiviral agent against coronavirus. Due to unique tri-peptide bonds and the formyl functional group, the bioassay of MPI8 in plasma was challenged by a strong interference from water MPI8. Using QTOF LC-MS/MS, we identified MPI8•H(2)O as the major interference...

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Detalles Bibliográficos
Autores principales: Wang, Yang, Xie, Huan, Alugubelli, Yugendar R., Ma, Yuying, Xu, Shiqing, Ma, Jing, Liu, Wenshe R., Liang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228185/
https://www.ncbi.nlm.nih.gov/pubmed/35745595
http://dx.doi.org/10.3390/ph15060676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228185/
https://www.ncbi.nlm.nih.gov/pubmed/35745595
http://dx.doi.org/10.3390/ph15060676

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