Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner

The flavivirus nonstructural protein 1 (NS1) is secreted from infected cells and contributes to endothelial barrier dysfunction and vascular leak in a tissue-dependent manner. This phenomenon occurs in part via disruption of the endothelial glycocalyx layer (EGL) lining the endothelium. Additionally...

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Detalhes bibliográficos
Autores principales: Puerta-Guardo, Henry, Biering, Scott B., de Sousa, Francielle Tramontini Gomes, Shu, Jeffrey, Glasner, Dustin R., Li, Jeffrey, Blanc, Sophie F., Beatty, P. Robert, Harris, Eva
Formato: Online Artigo Texto
Idioma:English
Publicado em: MDPI 2022
Assuntos:
Article
Acesso em linha:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228372/
https://www.ncbi.nlm.nih.gov/pubmed/35745469
http://dx.doi.org/10.3390/pathogens11060615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228372/
https://www.ncbi.nlm.nih.gov/pubmed/35745469
http://dx.doi.org/10.3390/pathogens11060615

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