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Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner

The flavivirus nonstructural protein 1 (NS1) is secreted from infected cells and contributes to endothelial barrier dysfunction and vascular leak in a tissue-dependent manner. This phenomenon occurs in part via disruption of the endothelial glycocalyx layer (EGL) lining the endothelium. Additionally...

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Detalles Bibliográficos
Autores principales:	Puerta-Guardo, Henry, Biering, Scott B., de Sousa, Francielle Tramontini Gomes, Shu, Jeffrey, Glasner, Dustin R., Li, Jeffrey, Blanc, Sophie F., Beatty, P. Robert, Harris, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228372/ https://www.ncbi.nlm.nih.gov/pubmed/35745469 http://dx.doi.org/10.3390/pathogens11060615

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