Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study

Human dihydroorotate dehydrogenase (hDHODH) is an enzyme belonging to a flavin mononucleotide (FMN)-dependent family involved in de novo pyrimidine biosynthesis, a key biological pathway for highly proliferating cancer cells and pathogens. In fact, hDHODH proved to be a promising therapeutic target...

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Detalles Bibliográficos
Autores principales: Galati, Salvatore, Sainas, Stefano, Giorgis, Marta, Boschi, Donatella, Lolli, Marco L., Ortore, Gabriella, Poli, Giulio, Tuccinardi, Tiziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228440/
https://www.ncbi.nlm.nih.gov/pubmed/35744791
http://dx.doi.org/10.3390/molecules27123660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228440/
https://www.ncbi.nlm.nih.gov/pubmed/35744791
http://dx.doi.org/10.3390/molecules27123660

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