Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression

Screening of a protein kinase inhibitor library identified SB431542, targeting activin receptor-like kinase 5 (ALK5), as a compound interfering with SARS-CoV-2 replication. Since ALK5 is implicated in transforming growth factor β (TGF-β) signaling and regulation of the cellular endoprotease furin, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Mezger, Maja C., Conzelmann, Carina, Weil, Tatjana, von Maltitz, Pascal, Albers, Dan P. J., Münch, Jan, Stamminger, Thomas, Schilling, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228453/
https://www.ncbi.nlm.nih.gov/pubmed/35746781
http://dx.doi.org/10.3390/v14061308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228453/
https://www.ncbi.nlm.nih.gov/pubmed/35746781
http://dx.doi.org/10.3390/v14061308

Ejemplares similares