Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning

[Image: see text] Promiscuous post-translational modification (PTM) enzymes often display nonobvious substrate preferences by acting on diverse yet well-defined sets of peptides and/or proteins. Understanding of substrate fitness landscapes for PTM enzymes is important in many areas of contemporary...

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Detalles Bibliográficos
Autores principales: Vinogradov, Alexander A., Chang, Jun Shi, Onaka, Hiroyasu, Goto, Yuki, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228559/
https://www.ncbi.nlm.nih.gov/pubmed/35756369
http://dx.doi.org/10.1021/acscentsci.2c00223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228559/
https://www.ncbi.nlm.nih.gov/pubmed/35756369
http://dx.doi.org/10.1021/acscentsci.2c00223

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