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Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning

[Image: see text] Promiscuous post-translational modification (PTM) enzymes often display nonobvious substrate preferences by acting on diverse yet well-defined sets of peptides and/or proteins. Understanding of substrate fitness landscapes for PTM enzymes is important in many areas of contemporary...

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Detalles Bibliográficos
Autores principales:	Vinogradov, Alexander A., Chang, Jun Shi, Onaka, Hiroyasu, Goto, Yuki, Suga, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228559/ https://www.ncbi.nlm.nih.gov/pubmed/35756369 http://dx.doi.org/10.1021/acscentsci.2c00223

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