Development of Abiraterone Acetate Nanocrystal Tablets to Enhance Oral Bioavailability: Formulation Optimization, Characterization, In Vitro Dissolution and Pharmacokinetic Evaluation

Abiraterone acetate is a prodrug of abiraterone used in combination with prednisone as a standard therapeutic strategy for hormone-resistant prostate cancer (mCRPC). Due to the poor solubility and permeability, the release and absorption of abiraterone acetate are low and reduce its bioavailability....

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Detalles Bibliográficos
Autores principales: Liu, Yuanfen, Li, Yuqi, Xu, Pengcheng, Shen, Yan, Tang, Baoqiang, Wang, Qiyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228621/
https://www.ncbi.nlm.nih.gov/pubmed/35745707
http://dx.doi.org/10.3390/pharmaceutics14061134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228621/
https://www.ncbi.nlm.nih.gov/pubmed/35745707
http://dx.doi.org/10.3390/pharmaceutics14061134

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