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Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos

The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food c...

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Autores principales: Tarazona, Jose V., González-Caballero, Maria del Carmen, de Alba-Gonzalez, Mercedes, Pedraza-Diaz, Susana, Cañas, Ana, Dominguez-Morueco, Noelia, Esteban-López, Marta, Cattaneo, Irene, Katsonouri, Andromachi, Makris, Konstantinos C., Halldorsson, Thorhallur I., Olafsdottir, Kristin, Zock, Jan-Paul, Dias, Jonatan, Decker, Annelies De, Morrens, Bert, Berman, Tamar, Barnett-Itzhaki, Zohar, Lindh, Christian, Gilles, Liese, Govarts, Eva, Schoeters, Greet, Weber, Till, Kolossa-Gehring, Marike, Santonen, Tiina, Castaño, Argelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228629/
https://www.ncbi.nlm.nih.gov/pubmed/35736921
http://dx.doi.org/10.3390/toxics10060313
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author Tarazona, Jose V.
González-Caballero, Maria del Carmen
de Alba-Gonzalez, Mercedes
Pedraza-Diaz, Susana
Cañas, Ana
Dominguez-Morueco, Noelia
Esteban-López, Marta
Cattaneo, Irene
Katsonouri, Andromachi
Makris, Konstantinos C.
Halldorsson, Thorhallur I.
Olafsdottir, Kristin
Zock, Jan-Paul
Dias, Jonatan
Decker, Annelies De
Morrens, Bert
Berman, Tamar
Barnett-Itzhaki, Zohar
Lindh, Christian
Gilles, Liese
Govarts, Eva
Schoeters, Greet
Weber, Till
Kolossa-Gehring, Marike
Santonen, Tiina
Castaño, Argelia
author_facet Tarazona, Jose V.
González-Caballero, Maria del Carmen
de Alba-Gonzalez, Mercedes
Pedraza-Diaz, Susana
Cañas, Ana
Dominguez-Morueco, Noelia
Esteban-López, Marta
Cattaneo, Irene
Katsonouri, Andromachi
Makris, Konstantinos C.
Halldorsson, Thorhallur I.
Olafsdottir, Kristin
Zock, Jan-Paul
Dias, Jonatan
Decker, Annelies De
Morrens, Bert
Berman, Tamar
Barnett-Itzhaki, Zohar
Lindh, Christian
Gilles, Liese
Govarts, Eva
Schoeters, Greet
Weber, Till
Kolossa-Gehring, Marike
Santonen, Tiina
Castaño, Argelia
author_sort Tarazona, Jose V.
collection PubMed
description The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food consumption patterns, according to internationally agreed procedures. In addition, jurisdictions such as the European Union (EU) have implemented large monitoring programs, measuring actual pesticide residue levels in food, and are supporting large-scale human biomonitoring programs for confirming the actual exposure levels and potential risk for consumers. The organophosphate insecticide chlorpyrifos offers an interesting case study, as in the last decade, its acceptable daily intake (ADI) has been reduced several times following risk assessments by the European Food Safety Authority (EFSA). This process has been linked to significant reductions in the use authorized in the EU, reducing consumers’ exposure progressively, until the final ban in 2020, accompanied by setting all EU maximum residue levels (MRL) in food at the default value of 0.01 mg/kg. We present a comparison of estimates of the consumer’s internal exposure to chlorpyrifos based on the urinary marker 3,5,6-trichloro-2-pyridinol (TCPy), using two sources of monitoring data: monitoring of the food chain from the EU program and biomonitoring of European citizens from the HB4EU project, supported by a literature search. Both methods confirmed a drastic reduction in exposure levels from 2016 onwards. The margin of exposure approach is then used for conducting retrospective risk assessments at different time points, considering the evolution of our understanding of chlorpyrifos toxicity, as well as of exposure levels in EU consumers following the regulatory decisions. Concerns are presented using a color code, and have been identified for almost all studies, particularly for the highest exposed group, but at different levels, reaching the maximum level, red code, for children in Cyprus and Israel. The assessment uncertainties are highlighted and integrated in the identification of levels of concern.
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spelling pubmed-92286292022-06-25 Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos Tarazona, Jose V. González-Caballero, Maria del Carmen de Alba-Gonzalez, Mercedes Pedraza-Diaz, Susana Cañas, Ana Dominguez-Morueco, Noelia Esteban-López, Marta Cattaneo, Irene Katsonouri, Andromachi Makris, Konstantinos C. Halldorsson, Thorhallur I. Olafsdottir, Kristin Zock, Jan-Paul Dias, Jonatan Decker, Annelies De Morrens, Bert Berman, Tamar Barnett-Itzhaki, Zohar Lindh, Christian Gilles, Liese Govarts, Eva Schoeters, Greet Weber, Till Kolossa-Gehring, Marike Santonen, Tiina Castaño, Argelia Toxics Article The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food consumption patterns, according to internationally agreed procedures. In addition, jurisdictions such as the European Union (EU) have implemented large monitoring programs, measuring actual pesticide residue levels in food, and are supporting large-scale human biomonitoring programs for confirming the actual exposure levels and potential risk for consumers. The organophosphate insecticide chlorpyrifos offers an interesting case study, as in the last decade, its acceptable daily intake (ADI) has been reduced several times following risk assessments by the European Food Safety Authority (EFSA). This process has been linked to significant reductions in the use authorized in the EU, reducing consumers’ exposure progressively, until the final ban in 2020, accompanied by setting all EU maximum residue levels (MRL) in food at the default value of 0.01 mg/kg. We present a comparison of estimates of the consumer’s internal exposure to chlorpyrifos based on the urinary marker 3,5,6-trichloro-2-pyridinol (TCPy), using two sources of monitoring data: monitoring of the food chain from the EU program and biomonitoring of European citizens from the HB4EU project, supported by a literature search. Both methods confirmed a drastic reduction in exposure levels from 2016 onwards. The margin of exposure approach is then used for conducting retrospective risk assessments at different time points, considering the evolution of our understanding of chlorpyrifos toxicity, as well as of exposure levels in EU consumers following the regulatory decisions. Concerns are presented using a color code, and have been identified for almost all studies, particularly for the highest exposed group, but at different levels, reaching the maximum level, red code, for children in Cyprus and Israel. The assessment uncertainties are highlighted and integrated in the identification of levels of concern. MDPI 2022-06-09 /pmc/articles/PMC9228629/ /pubmed/35736921 http://dx.doi.org/10.3390/toxics10060313 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tarazona, Jose V.
González-Caballero, Maria del Carmen
de Alba-Gonzalez, Mercedes
Pedraza-Diaz, Susana
Cañas, Ana
Dominguez-Morueco, Noelia
Esteban-López, Marta
Cattaneo, Irene
Katsonouri, Andromachi
Makris, Konstantinos C.
Halldorsson, Thorhallur I.
Olafsdottir, Kristin
Zock, Jan-Paul
Dias, Jonatan
Decker, Annelies De
Morrens, Bert
Berman, Tamar
Barnett-Itzhaki, Zohar
Lindh, Christian
Gilles, Liese
Govarts, Eva
Schoeters, Greet
Weber, Till
Kolossa-Gehring, Marike
Santonen, Tiina
Castaño, Argelia
Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos
title Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos
title_full Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos
title_fullStr Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos
title_full_unstemmed Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos
title_short Improving the Risk Assessment of Pesticides through the Integration of Human Biomonitoring and Food Monitoring Data: A Case Study for Chlorpyrifos
title_sort improving the risk assessment of pesticides through the integration of human biomonitoring and food monitoring data: a case study for chlorpyrifos
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228629/
https://www.ncbi.nlm.nih.gov/pubmed/35736921
http://dx.doi.org/10.3390/toxics10060313
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