Design of Novel Enantiopure Dispirooxindolopyrrolidine-Piperidones as Promising Candidates toward COVID-19: Asymmetric Synthesis, Crystal Structure and In Silico Studies

Despite the effectiveness of COVID-19 vaccines, there is still an urgent need for discovering new anti-viral drugs to address the awful spread and transmission of the rapidly modifiable virus. In this study, the ability of a small library of enantiomerically pure spirooxindolopyrrolidine-grafted pip...

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Detalles Bibliográficos
Autores principales: Toumi, Amani, Boudriga, Sarra, Mandour, Yasmine M., Mekki, Ahmed A., Knorr, Michael, Strohmann, Carsten, Kirchhoff, Jan-Lukas, Sobeh, Mansour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228936/
https://www.ncbi.nlm.nih.gov/pubmed/35745069
http://dx.doi.org/10.3390/molecules27123945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228936/
https://www.ncbi.nlm.nih.gov/pubmed/35745069
http://dx.doi.org/10.3390/molecules27123945

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