Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents

Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (7a–ad) and variably substituted anilines (8a–v) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-a]pyrimidine nucleus, had moderate to potent antiproliferative activity against A549, MDA-MB-231, HeLa, HT-29...

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Detalles Bibliográficos
Autores principales: Oliva, Paola, Romagnoli, Romeo, Cacciari, Barbara, Manfredini, Stefano, Padroni, Chiara, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Corallo, Diana, Aveic, Sanja, Milan, Noemi, Mariotto, Elena, Viola, Giampietro, Bortolozzi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230136/
https://www.ncbi.nlm.nih.gov/pubmed/35745764
http://dx.doi.org/10.3390/pharmaceutics14061191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230136/
https://www.ncbi.nlm.nih.gov/pubmed/35745764
http://dx.doi.org/10.3390/pharmaceutics14061191

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