Application of In Silico Filtering and Isothermal Titration Calorimetry for the Discovery of Small Molecule Inhibitors of MDM2

The initial discovery phase of protein modulators, which consists of filtering molecular libraries and in vitro direct binding validation, is central in drug discovery. Thus, virtual screening of large molecular libraries, together with the evaluation of binding affinity by isothermal calorimetry, g...

Descripción completa

Detalles Bibliográficos
Autores principales: Alali, Hen, Bloch, Itai, Rapaport, Irena, Rodrigues, Luisa, Sher, Inbal, Ansbacher, Tamar, Gal, Maayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230431/
https://www.ncbi.nlm.nih.gov/pubmed/35745671
http://dx.doi.org/10.3390/ph15060752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230431/
https://www.ncbi.nlm.nih.gov/pubmed/35745671
http://dx.doi.org/10.3390/ph15060752

Ejemplares similares