Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes. Therefore, improving GLP-1 receptor agonist (GLP-1RA) stability is a major obstacle for drug development. We analyzed human GLP-1, DPP-4, and G...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Zheng, Zhi-Ming, Shao, Chang-Sheng, Zhang, Zhi-Yong, Li, Ming-Wei, Wang, Li, Wang, Han, Zhao, Gen-Hai, Wang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230455/
https://www.ncbi.nlm.nih.gov/pubmed/35745659
http://dx.doi.org/10.3390/ph15060740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230455/
https://www.ncbi.nlm.nih.gov/pubmed/35745659
http://dx.doi.org/10.3390/ph15060740

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