Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against three key proteases involved in SARS-CoV-2 replication, incl...

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Detalles Bibliográficos
Autores principales: Meewan, Ittipat, Kattoula, Jacob, Kattoula, Julius Y., Skinner, Danielle, Fajtová, Pavla, Giardini, Miriam A., Woodworth, Brendon, McKerrow, James H., Lage de Siqueira-Neto, Jair, O’Donoghue, Anthony J., Abagyan, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230533/
https://www.ncbi.nlm.nih.gov/pubmed/35745663
http://dx.doi.org/10.3390/ph15060744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230533/
https://www.ncbi.nlm.nih.gov/pubmed/35745663
http://dx.doi.org/10.3390/ph15060744

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