Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX

A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities. Among them, compound A13 exhibited the most potent affinity toward MDM2 and MDMX, with a K(i) of 0.031 and 7.24 μM,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yali, Ji, Bo, Cheng, Zhongshui, Zhang, Lianghui, Cheng, Yingying, Li, Yingying, Ren, Jin, Liu, Wenbo, Ma, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230548/
https://www.ncbi.nlm.nih.gov/pubmed/35744849
http://dx.doi.org/10.3390/molecules27123721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230548/
https://www.ncbi.nlm.nih.gov/pubmed/35744849
http://dx.doi.org/10.3390/molecules27123721

Ejemplares similares