Cargando…

(68)Ga-Labeled [Leu(13)ψThz(14)]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake

The gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled receptor that is overexpressed in many solid cancers and is a promising target for cancer imaging and therapy. However, high pancreas uptake is a major concern in the application of reported GRPR-targeting radiopharmaceuticals, par...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lei, Zhang, Zhengxing, Merkens, Helen, Zeisler, Jutta, Zhang, Chengcheng, Roxin, Aron, Tan, Ruiyan, Bénard, François, Lin, Kuo-Shyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230575/ https://www.ncbi.nlm.nih.gov/pubmed/35744904 http://dx.doi.org/10.3390/molecules27123777

Ejemplares similares

(68)Ga-Labeled [Thz(14)]Bombesin(7–14) Analogs: Promising GRPR-Targeting Agonist PET Tracers with Low Pancreas Uptake
por: Wang, Lei, et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of Three Novel (68)Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging
por: Verena, Arsyangela, et al.
Publicado: (2023)

Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue
por: Lau, Joseph, et al.
Publicado: (2019)

Novel (68)Ga-Labeled Pyridine-Based Fibroblast Activation Protein-Targeted Tracers with High Tumor-to-Background Contrast
por: Verena, Arsyangela, et al.
Publicado: (2023)

Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics
por: Bendre, Shreya, et al.
Publicado: (2020)

What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake
por: Kuo, Hsiou-Ting, et al.
Publicado: (2022)

Synthesis and Evaluation of (68)Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging
por: Bendre, Shreya, et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of Novel (68)Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging
por: Bendre, Shreya, et al.
Publicado: (2023)

(18)F-Labeled Cyclized α-Melanocyte-Stimulating Hormone Derivatives for Imaging Human Melanoma Xenograft with Positron Emission Tomography
por: Zhang, Chengcheng, et al.
Publicado: (2019)

Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple N-Methylations for Melanoma Imaging with Positron Emission Tomography
por: Zhang, Chengcheng, et al.
Publicado: (2020)

High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
por: Mitran, Bogdan, et al.
Publicado: (2017)

Reducing the Kidney Uptake of High Contrast CXCR4 PET Imaging Agents via Linker Modifications
por: Kwon, Daniel, et al.
Publicado: (2022)

One-Step (18)F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging
por: Kuo, Hsiou-Ting, et al.
Publicado: (2019)

Monosodium Glutamate Reduces (68)Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model
por: Rousseau, Etienne, et al.
Publicado: (2018)

Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
por: Kuo, Hsiou-Ting, et al.
Publicado: (2023)

Targeting Refractory Mantle Cell Lymphoma for Imaging and Therapy Using C-X-C Chemokine Receptor Type 4 Radioligands
por: Kwon, Daniel, et al.
Publicado: (2022)

Synthesis and Evaluation of (99m)Tc-Labeled PSMA-Targeted Tracers Based on the Lys-Urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography
por: Lu, Kelly, et al.
Publicado: (2023)

Preclinical Melanoma Imaging with (68)Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET
por: Zhang, Chengcheng, et al.
Publicado: (2017)

In Vitro and In Vivo Evaluation of a (18)F-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging
por: Varasteh, Zohreh, et al.
Publicado: (2013)

Evaluating [(68)Ga]Ga-p14-032 as a Novel PET Tracer for Diagnosis Cerebral Amyloid Angiopathy
por: Zhang, Qihui, et al.
Publicado: (2021)

Radiolabeled Bombesin Analogs
por: Mansi, Rosalba, et al.
Publicado: (2021)

Evaluation of (99m)Tc-HYNIC-βAla-Bombesin((7-14)) as an agent for pancreas tumor detection in mice
por: Carlesso, F.N., et al.
Publicado: (2015)

Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer
por: Mitran, Bogdan, et al.
Publicado: (2019)

Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography
por: Dude, Iulia, et al.
Publicado: (2017)

Measurement of the production of the J/ψ and ψ(2S) mesons and study of the decay χb → J/ψJ/ψ with the ATLAS detector at LHC
por: Karakostas, Konstantinos
Publicado: (2015)

Exclusive $J/ψ$ and $ψ(2S)$ Vector Meson Production
por: Rangel, Murilo
Publicado: (2014)

Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer
por: Abouzayed, Ayman, et al.
Publicado: (2020)

(68)Ga-BBN-RGD PET/CT for GRPR and Integrin α(v)β(3) Imaging in Patients with Breast Cancer
por: Zhang, Jingjing, et al.
Publicado: (2018)

GRPR-targeting radiotheranostics for breast cancer management
por: D’Onofrio, Alice, et al.
Publicado: (2023)

GRPR versus PSMA: expression profiles during prostate cancer progression demonstrate the added value of GRPR-targeting theranostic approaches
por: Verhoeven, Marjolein, et al.
Publicado: (2023)

Bombesin and bombesin antagonists: studies in Swiss 3T3 cells and human small cell lung cancer.
por: Woll, P. J., et al.
Publicado: (1988)

Role of the neuropeptide, bombesin, in bile secretion.
por: Cho, W. K.
Publicado: (1997)

Targeting prostate cancer with radiolabelled bombesins
por: Maina, Theodosia, et al.
Publicado: (2006)

Phase I Trial of [(99m)Tc]Tc-maSSS-PEG(2)-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors
por: Chernov, Vladimir, et al.
Publicado: (2023)

Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers
por: D’Onofrio, Alice, et al.
Publicado: (2022)

(68)Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation
por: Hajiramezanali, Maliheh, et al.
Publicado: (2019)

Measurement of relative branching fractions of B decays to ψ(2S) and J/ψ mesons
por: Aaij, R., et al.
Publicado: (2012)

J/ψ Production in ATLAS
por: Yang, Yi
Publicado: (2012)

Comparison between (68)Ga-bombesin ((68)Ga-BZH3) and the cRGD tetramer (68)Ga-RGD(4 )studies in an experimental nude rat model with a neuroendocrine pancreatic tumor cell line
por: Cheng, Caixia, et al.
Publicado: (2011)

Synthesis of DOTA-pyridine chelates for (64)Cu coordination and radiolabeling of αMSH peptide
por: Yang, Hua, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7lrnpdph3jbcj0j28e5u71urk6