Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells

Ovarian cancer accounts for 3% of the total cancers in women, yet it is the fifth leading cause of cancer deaths among women. The BRCA1/2 germline and somatic mutations confer a deficiency of the homologous recombination (HR) repair pathway. Inhibitors of poly (ADP-ribose) polymerase (PARP), another...

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Detalles Bibliográficos
Autores principales: El Naggar, Olivia, Doyle, Brenna, Mariner, Kelsey, Gilmour, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230675/
https://www.ncbi.nlm.nih.gov/pubmed/35736348
http://dx.doi.org/10.3390/medsci10020028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230675/
https://www.ncbi.nlm.nih.gov/pubmed/35736348
http://dx.doi.org/10.3390/medsci10020028

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