Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors

Sixteen compounds (TR1–TR16) were synthesized and evaluated for their inhibitory activities against monoamine oxidase A and B (MAOs). Most of the derivatives showed potent and highly selective MAO-B inhibition. Compound TR16 was the most potent inhibitor against MAO-B with an IC(50) value of 0.17 μM...

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Detalles Bibliográficos
Autores principales: Alagöz, Mehmet Abdullah, Oh, Jong Min, Zenni, Yaren Nur, Özdemir, Zeynep, Abdelgawad, Mohamed A., Naguib, Ibrahim A., Ghoneim, Mohammed M., Gambacorta, Nicola, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230784/
https://www.ncbi.nlm.nih.gov/pubmed/35744926
http://dx.doi.org/10.3390/molecules27123801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230784/
https://www.ncbi.nlm.nih.gov/pubmed/35744926
http://dx.doi.org/10.3390/molecules27123801

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