Uncovering the Molecular Basis for the Better Gefitinib Sensitivity of EGFR with Complex Mutations over Single Rare Mutation: Insights from Molecular Simulations

Epidermal growth factor receptor (EGFR) is an intensively focused target for anti-tumor compounds used in non-small cell lung cancer (NSCLC) therapy. Compared to the classical activating mutations, there are still many uncommon EGFR mutations associated with poorer responses to EGFR inhibitors. A de...

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Detalles Bibliográficos
Autores principales: Li, Miaomiao, Li, Mengrong, Xie, Yanjie, Guo, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230809/
https://www.ncbi.nlm.nih.gov/pubmed/35744964
http://dx.doi.org/10.3390/molecules27123844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230809/
https://www.ncbi.nlm.nih.gov/pubmed/35744964
http://dx.doi.org/10.3390/molecules27123844

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