Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid

Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Catalyzed by hepatic cytochrome P450 enzymes, PAs are metabolized into reactive pyrrolic metabolites, which can alkylate cellular proteins and DNA to form pyrrole-protei...

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Detalles Bibliográficos
Autores principales: Zhu, Lin, Xue, Junyi, He, Yisheng, Xia, Qingsu, Fu, Peter P., Lin, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231038/
https://www.ncbi.nlm.nih.gov/pubmed/35737038
http://dx.doi.org/10.3390/toxins14060377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231038/
https://www.ncbi.nlm.nih.gov/pubmed/35737038
http://dx.doi.org/10.3390/toxins14060377

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