Cargando…

Bio-Oriented Synthesis of Novel (S)-Flurbiprofen Clubbed Hydrazone Schiff’s Bases for Diabetic Management: In Vitro and In Silico Studies

A new series of (S)-flurbiprofen derivatives 4a–4p and 5a–5n were synthesized with different aromatic or aliphatic aldehydes and ketones to produce Schiff’s bases and their structures were confirmed through HR-ESI-MS, (1)H, and (13)C-NMR spectroscopy. The α-glucosidase inhibitory activities of the n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alam, Aftab, Ali, Mumtaz, Rehman, Najeeb Ur, Ullah, Saeed, Halim, Sobia Ahsan, Latif, Abdul, Zainab, Khan, Ajmal, Ullah, Obaid, Ahmad, Shujaat, Al-Harrasi, Ahmed, Ahmad, Manzoor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231348/ https://www.ncbi.nlm.nih.gov/pubmed/35745591 http://dx.doi.org/10.3390/ph15060672

Ejemplares similares

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes
por: Talab, Faiz, et al.
Publicado: (2023)

2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer’s therapy: In vitro, kinetic, in silico, and in vivo potentials
por: Begum, Farida, et al.
Publicado: (2022)

Novel Polyhydroquinoline-Hydrazide-Linked Schiff’s Base Derivatives: Multistep Synthesis, Antimicrobial, and Calcium-Channel-Blocking Activities
por: Zainab,, et al.
Publicado: (2022)

Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
por: Tariq, Hafiza Zara, et al.
Publicado: (2023)

New supramolecules of bis(acylhydrazones)-linked bisphenol sulfide for Alzheimer's: targeting cholinesterases by in vitro and in silico approaches
por: Ibrahim, Muhammad, et al.
Publicado: (2023)

Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors
por: Rafiq, Kashif, et al.
Publicado: (2022)

Enzymes Inhibition and Antioxidant Potential of Medicinal Plants Growing in Oman
por: Rehman, Najeeb Ur, et al.
Publicado: (2022)

Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study
por: Ahmad, Sajjad, et al.
Publicado: (2023)

Discovery of New Boswellic Acid Hybrid 1H-1,2,3-Triazoles for Diabetic Management: In Vitro and In Silico Studies
por: Rehman, Najeeb Ur, et al.
Publicado: (2023)

Identification of α-Glucosidase Inhibitors from Scutellaria edelbergii: ESI-LC-MS and Computational Approach
por: Shah, Muddaser, et al.
Publicado: (2022)

Bio-Potency and Molecular Docking Studies of Isolated Compounds from Grewia optiva J.R. Drumm. ex Burret
por: Ul Bari, Wasim, et al.
Publicado: (2021)

Antiproliferative and Carbonic Anhydrase II Inhibitory Potential of Chemical Constituents from Lycium shawii and Aloe vera: Evidence from In Silico Target Fishing and In Vitro Testing
por: Ur Rehman, Najeeb, et al.
Publicado: (2020)

Antiamnesic Effects of Novel Phthalimide Derivatives in Scopolamine-Induced Memory Impairment in Mice: A Useful Therapy for Alzheimer’s Disease
por: Karim, Nasiara, et al.
Publicado: (2023)

Novel 5-(Arylideneamino)-1H-Benzo[d]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies
por: Ali, Sardar, et al.
Publicado: (2022)

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach
por: Shah, Muddaser, et al.
Publicado: (2021)

Optimization of Chitosan-Decorated Solid Lipid Nanoparticles for Improved Flurbiprofen Transdermal Delivery
por: Burki, Firdous Ahmad, et al.
Publicado: (2023)

Triterpenic Acids as Non-Competitive α-Glucosidase Inhibitors from Boswellia elongata with Structure-Activity Relationship: In Vitro and In Silico Studies
por: Ur Rehman, Najeeb, et al.
Publicado: (2020)

Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches
por: Pasha, Anam Rubbab, et al.
Publicado: (2023)

New Carbonic Anhydrase-II Inhibitors from Marine Macro Brown Alga Dictyopteris hoytii Supported by In Silico Studies
por: Rafiq, Kashif, et al.
Publicado: (2021)

Sonophotocatalytic Degradation of Fast Yellow AB and Remazol Brilliant Violet-5R by Using Ag-Impregnated ZnO as a Photocatalyst
por: Aziz, Nosheen, et al.
Publicado: (2023)

Aroma Profile and Biological Effects of Ochradenus arabicus Essential Oils: A Comparative Study of Stem, Flowers, and Leaves
por: Ullah, Obaid, et al.
Publicado: (2022)

α-Glucosidase Inhibition and Molecular Docking Studies of Natural Brominated Metabolites from Marine Macro Brown Alga Dictyopteris hoytii
por: Ur Rehman, Najeeb, et al.
Publicado: (2019)

Mercaptobenzimidazole-Based 1,3-Thaizolidin-4-ones as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, and Molecular Docking Studies
por: Khan, Sher Ali, et al.
Publicado: (2022)

Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors
por: Rasool, Asif, et al.
Publicado: (2022)

A novel variant of GALC in a familial case of Krabbe disease: Insights from structural bioinformatics and molecular dynamics simulation
por: Ullah, Ikram, et al.
Publicado: (2023)

Antiamnesic Effects of Feralolide Isolated from Aloe vera Resin Miller against Learning Impairments Induced in Mice
por: Khan, Imran, et al.
Publicado: (2023)

In Silico Prediction of Novel Inhibitors of SARS-CoV-2 Main Protease through Structure-Based Virtual Screening and Molecular Dynamic Simulation
por: Halim, Sobia Ahsan, et al.
Publicado: (2021)

Rational Design of Novel Inhibitors of α-Glucosidase: An Application of Quantitative Structure Activity Relationship and Structure-Based Virtual Screening
por: Halim, Sobia Ahsan, et al.
Publicado: (2021)

GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
por: Shah, Muddaser, et al.
Publicado: (2021)

Rifampicin conjugated silver nanoparticles: a new arena for development of antibiofilm potential against methicillin resistant Staphylococcus aureus and Klebsiella pneumoniae
por: Farooq, Umar, et al.
Publicado: (2019)

Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach
por: Avula, Satya Kumar, et al.
Publicado: (2023)

Design, Synthesis, Crystal Structure, In Vitro and In Silico Evaluation of New N′-Benzylidene-4-tert-butylbenzohydrazide Derivatives as Potent Urease Inhibitors
por: Ahmad, Sajjad, et al.
Publicado: (2022)

In Silico Modeling of Crimean Congo Hemorrhagic Fever Virus Glycoprotein-N and Screening of Anti Viral Hits by Virtual Screening
por: Halim, Sobia Ahsan, et al.
Publicado: (2020)

Multi-Fold Computational Analysis to Discover Novel Putative Inhibitors of Isethionate Sulfite-Lyase (Isla) from Bilophila wadsworthia: Combating Colorectal Cancer and Inflammatory Bowel Diseases
por: Waqas, Muhammad, et al.
Publicado: (2023)

Triazolothiadiazoles and Triazolothiadiazines as New and Potent Urease Inhibitors: Insights from In Vitro Assay, Kinetics Data, and In Silico Assessment
por: Uddin, Jalal, et al.
Publicado: (2023)

Recent Advances in Electrochemical Sensing of Hydrogen Peroxide (H(2)O(2)) Released from Cancer Cells
por: Ahmad, Touqeer, et al.
Publicado: (2022)

GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report
por: Shah, Muddaser, et al.
Publicado: (2023)

Diterpenoids and Triterpenoids From Frankincense Are Excellent Anti-psoriatic Agents: An in silico Approach
por: Halim, Sobia Ahsan, et al.
Publicado: (2020)

Genome Subtraction and Comparison for the Identification of Novel Drug Targets against Mycobacterium avium subsp. hominissuis
por: Uddin, Reaz, et al.
Publicado: (2020)

Bridging the Chemical Profile and Biomedical Effects of Scutellaria edelbergii Essential Oils
por: Shah, Muddaser, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l4n8uaif75n84qm8h1ppo0388t