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26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase
Heat shock (HS) promotes protein unfolding, and cells respond by stimulating HS gene expression, ubiquitination of cell proteins, and proteolysis by the proteasome. Exposing HeLa and other cells to 43 °C for 2 h caused a twofold increase in the 26S proteasomes’ peptidase activity assayed at 37 °C. T...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231471/ https://www.ncbi.nlm.nih.gov/pubmed/35704754 http://dx.doi.org/10.1073/pnas.2122482119 |