Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFNγ-dependent mortality in STING gain-of-function mice

Pediatric patients with constitutively active mutations in the cytosolic double-stranded-DNA-sensing adaptor STING develop an autoinflammatory syndrome known as STING-associated vasculopathy with onset in infancy (SAVI). SAVI patients have elevated interferon-stimulated gene expression and suffer fr...

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Detalles Bibliográficos
Autores principales: Gao, Kevin MingJie, Motwani, Mona, Tedder, Thomas, Marshak-Rothstein, Ann, Fitzgerald, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231608/
https://www.ncbi.nlm.nih.gov/pubmed/35696583
http://dx.doi.org/10.1073/pnas.2202327119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231608/
https://www.ncbi.nlm.nih.gov/pubmed/35696583
http://dx.doi.org/10.1073/pnas.2202327119

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