Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease

Cortical neuron loss is a pathological hallmark of late-onset Alzheimer’s disease (AD). However, it remains unclear which neuronal subtypes beyond broad excitatory and inhibitory classes are most vulnerable. Here, we analyzed cell subtype proportion differences in AD compared to non-AD controls usin...

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Detalles Bibliográficos
Autores principales: Consens, Micaela E., Chen, Yuxiao, Menon, Vilas, Wang, Yanling, Schneider, Julie A., De Jager, Philip L., Bennett, David A., Tripathy, Shreejoy J., Felsky, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231610/
https://www.ncbi.nlm.nih.gov/pubmed/35754708
http://dx.doi.org/10.3389/fnmol.2022.903175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231610/
https://www.ncbi.nlm.nih.gov/pubmed/35754708
http://dx.doi.org/10.3389/fnmol.2022.903175

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