Spatio-temporal dynamics of pathogenic variants associated with monogenic disorders reconstructed with ancient DNA

Genetic disease burden in ancient communities has barely been evaluated despite an ever expanding body of ancient genomes becoming available. In this study, we inspect 2729 publicly available ancient genomes (100 BP—52000 BP) for the presence of pathogenic variants in 32643 disease-associated loci....

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Detalles Bibliográficos
Autores principales: Toncheva, Draga, Marinova, Maria, Borovska, Plamenka, Serbezov, Dimitar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231702/
https://www.ncbi.nlm.nih.gov/pubmed/35749392
http://dx.doi.org/10.1371/journal.pone.0269628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231702/
https://www.ncbi.nlm.nih.gov/pubmed/35749392
http://dx.doi.org/10.1371/journal.pone.0269628

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