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Spatio-temporal dynamics of pathogenic variants associated with monogenic disorders reconstructed with ancient DNA
Genetic disease burden in ancient communities has barely been evaluated despite an ever expanding body of ancient genomes becoming available. In this study, we inspect 2729 publicly available ancient genomes (100 BP—52000 BP) for the presence of pathogenic variants in 32643 disease-associated loci....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231702/ https://www.ncbi.nlm.nih.gov/pubmed/35749392 http://dx.doi.org/10.1371/journal.pone.0269628 |