Filamentation modulates allosteric regulation of PRPS

Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal regulation of PRPP synthase (PRPS) is associated with human disorders, including Arts syndrome, retinal dystrophy, and gouty...

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Detalles Bibliográficos
Autores principales: Hu, Huan-Huan, Lu, Guang-Ming, Chang, Chia-Chun, Li, Yilan, Zhong, Jiale, Guo, Chen-Jun, Zhou, Xian, Yin, Boqi, Zhang, Tianyi, Liu, Ji-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232217/
https://www.ncbi.nlm.nih.gov/pubmed/35736577
http://dx.doi.org/10.7554/eLife.79552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232217/
https://www.ncbi.nlm.nih.gov/pubmed/35736577
http://dx.doi.org/10.7554/eLife.79552

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