Cargando…

Filamentation modulates allosteric regulation of PRPS

Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal regulation of PRPP synthase (PRPS) is associated with human disorders, including Arts syndrome, retinal dystrophy, and gouty...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Huan-Huan, Lu, Guang-Ming, Chang, Chia-Chun, Li, Yilan, Zhong, Jiale, Guo, Chen-Jun, Zhou, Xian, Yin, Boqi, Zhang, Tianyi, Liu, Ji-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232217/ https://www.ncbi.nlm.nih.gov/pubmed/35736577 http://dx.doi.org/10.7554/eLife.79552

Ejemplares similares

Structural basis of dynamic P5CS filaments
por: Zhong, Jiale, et al.
Publicado: (2022)

Structural basis of human PRPS2 filaments
por: Lu, Guang-Ming, et al.
Publicado: (2023)

Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
por: Johnson, Matthew C, et al.
Publicado: (2020)

Allosteric modulation of the adenosine A(2A) receptor by cholesterol
por: Huang, Shuya Kate, et al.
Publicado: (2022)

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation
por: Kuenze, Georg, et al.
Publicado: (2020)

Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism
por: Guo, Jingjing, et al.
Publicado: (2016)

Side-binding proteins modulate actin filament dynamics
por: Crevenna, Alvaro H, et al.
Publicado: (2015)

Conserved allosteric inhibition mechanism in SLC1 transporters
por: Dong, Yang, et al.
Publicado: (2023)

Allosteric inhibition of the T cell receptor by a designed membrane ligand
por: Ye, Yujie, et al.
Publicado: (2023)

Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9
por: Nierzwicki, Lukasz, et al.
Publicado: (2021)

Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit
por: Igaev, Maxim, et al.
Publicado: (2018)

Gating mechanisms during actin filament elongation by formins
por: Aydin, Fikret, et al.
Publicado: (2018)

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation
por: Ruff, Emily F, et al.
Publicado: (2018)

The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels
por: Rinné, Susanne, et al.
Publicado: (2019)

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca(2+) and phosphorylation
por: Weber, Daniel K, et al.
Publicado: (2021)

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C
por: Chinthalapudi, Krishna, et al.
Publicado: (2017)

Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation
por: Wieteska, Lukasz, et al.
Publicado: (2017)

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
por: Keedy, Daniel A, et al.
Publicado: (2018)

Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels
por: Niu, Jacqueline, et al.
Publicado: (2018)

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
por: Subramanian, Subu, et al.
Publicado: (2021)

Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol
por: Manna, Moutusi, et al.
Publicado: (2016)

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
por: Zhang, Wenjuan, et al.
Publicado: (2019)

Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle
por: Zhang, Xuemeng, et al.
Publicado: (2017)

Allosteric signalling in the outer membrane translocation domain of PapC usher
por: Farabella, Irene, et al.
Publicado: (2014)

The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism
por: Stanisich, Jessica J, et al.
Publicado: (2020)

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
por: Lauer, Janelle, et al.
Publicado: (2019)

Correction: Allosteric signalling in the outer membrane translocation domain of PapC usher
por: Farabella, Irene, et al.
Publicado: (2016)

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
por: Wang, Zhao, et al.
Publicado: (2017)

Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties
por: Melli, Luca, et al.
Publicado: (2018)

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments
por: Barski, Michal, et al.
Publicado: (2017)

A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions
por: Alekseev, Aleksandr, et al.
Publicado: (2022)

An external sodium ion binding site controls allosteric gating in TRPV1 channels
por: Jara-Oseguera, Andres, et al.
Publicado: (2016)

Myosin motors fragment and compact membrane-bound actin filaments
por: Vogel, Sven K, et al.
Publicado: (2013)

A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
por: Geyer, Elisabeth A, et al.
Publicado: (2015)

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP
por: Chatterjee, Debashree, et al.
Publicado: (2014)

Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2014)

Model for a novel membrane envelope in a filamentous hyperthermophilic virus
por: Kasson, Peter, et al.
Publicado: (2017)

Correction: Structural basis for the prion-like MAVS filaments in antiviral innate immunity
por: Xu, Hui, et al.
Publicado: (2015)

Crenactin forms actin-like double helical filaments regulated by arcadin-2
por: Izoré, Thierry, et al.
Publicado: (2016)

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments
por: Tang, Shaogeng, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_26enq3mn51els9s55talaa6uhi