Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers

BACKGROUND AND OBJECTIVE: Combined acetaminophen and ibuprofen are common antipyretic and analgesic drugs. Formulation and feeding affect drug absorption. Drug clearance has a nonlinear relationship with total body weight. The covariate effect of fat mass on acetaminophen and ibuprofen pharmacokinet...

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Detalles Bibliográficos
Autores principales: Morse, James D., Stanescu, Ioana, Atkinson, Hartley C., Anderson, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232434/
https://www.ncbi.nlm.nih.gov/pubmed/35366213
http://dx.doi.org/10.1007/s13318-022-00766-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232434/
https://www.ncbi.nlm.nih.gov/pubmed/35366213
http://dx.doi.org/10.1007/s13318-022-00766-9

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