A multiparametric niche-like drug screening platform in acute myeloid leukemia

Functional precision medicine in AML often relies on short-term in vitro drug sensitivity screening (DSS) of primary patient cells in standard culture conditions. We designed a niche-like DSS assay combining physiologic hypoxia (O(2) 3%) and mesenchymal stromal cell (MSC) co-culture with multiparame...

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Detalles Bibliográficos
Autores principales: Dal Bello, Reinaldo, Pasanisi, Justine, Joudinaud, Romane, Duchmann, Matthieu, Pardieu, Bryann, Ayaka, Paolo, Di Feo, Giuseppe, Sodaro, Gaetano, Chauvel, Clémentine, Kim, Rathana, Vasseur, Loic, Chat, Laureen, Ling, Frank, Pacchiardi, Kim, Vaganay, Camille, Berrou, Jeannig, Benaksas, Chaima, Boissel, Nicolas, Braun, Thorsten, Preudhomme, Claude, Dombret, Hervé, Raffoux, Emmanuel, Fenouille, Nina, Clappier, Emmanuelle, Adès, Lionel, Puissant, Alexandre, Itzykson, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232632/
https://www.ncbi.nlm.nih.gov/pubmed/35750691
http://dx.doi.org/10.1038/s41408-022-00689-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232632/
https://www.ncbi.nlm.nih.gov/pubmed/35750691
http://dx.doi.org/10.1038/s41408-022-00689-3

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