BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding

Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluripotency. However, recent studies suggested that MEKi might cause irreversible defects that...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Mingzhu, Zhao, Kun, Liu, Meng, Wang, Mengting, Qiao, Zhibin, Yi, Shanru, Jiang, Yonghua, Kou, Xiaochen, Zhao, Yanhong, Yin, Jiqing, Li, Tianming, Wang, Hong, Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232672/
https://www.ncbi.nlm.nih.gov/pubmed/35147915
http://dx.doi.org/10.1007/s13238-021-00896-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232672/
https://www.ncbi.nlm.nih.gov/pubmed/35147915
http://dx.doi.org/10.1007/s13238-021-00896-x

Ejemplares similares