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BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding

Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluripotency. However, recent studies suggested that MEKi might cause irreversible defects that...

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Detalles Bibliográficos
Autores principales:	Wang, Mingzhu, Zhao, Kun, Liu, Meng, Wang, Mengting, Qiao, Zhibin, Yi, Shanru, Jiang, Yonghua, Kou, Xiaochen, Zhao, Yanhong, Yin, Jiqing, Li, Tianming, Wang, Hong, Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232672/ https://www.ncbi.nlm.nih.gov/pubmed/35147915 http://dx.doi.org/10.1007/s13238-021-00896-x

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