Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs

Recruiting endogenous adenosine deaminases using exogenous guide RNAs to edit cellular RNAs is a promising therapeutic strategy, but editing efficiency and durability remains low using current guide RNA designs. We engineered circular ADAR recruiting guide RNAs (cadRNAs) to enable more efficient pro...

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Detalles Bibliográficos
Autores principales: Katrekar, Dhruva, Yen, James, Xiang, Yichen, Saha, Anushka, Meluzzi, Dario, Savva, Yiannis, Mali, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232839/
https://www.ncbi.nlm.nih.gov/pubmed/35145312
http://dx.doi.org/10.1038/s41587-021-01171-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232839/
https://www.ncbi.nlm.nih.gov/pubmed/35145312
http://dx.doi.org/10.1038/s41587-021-01171-4

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