Cargando…

Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs

Recruiting endogenous adenosine deaminases using exogenous guide RNAs to edit cellular RNAs is a promising therapeutic strategy, but editing efficiency and durability remains low using current guide RNA designs. We engineered circular ADAR recruiting guide RNAs (cadRNAs) to enable more efficient pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katrekar, Dhruva, Yen, James, Xiang, Yichen, Saha, Anushka, Meluzzi, Dario, Savva, Yiannis, Mali, Prashant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232839/ https://www.ncbi.nlm.nih.gov/pubmed/35145312 http://dx.doi.org/10.1038/s41587-021-01171-4

Ejemplares similares

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity
por: Katrekar, Dhruva, et al.
Publicado: (2022)

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases
por: Katrekar, Dhruva, et al.
Publicado: (2019)

RNA editing: Expanding the potential of RNA therapeutics
por: Booth, Brian J., et al.
Publicado: (2023)

The ADAR protein family
por: Savva, Yiannis A, et al.
Publicado: (2012)

Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein
por: Bhogal, Balpreet, et al.
Publicado: (2011)

Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs
por: Vogel, Paul, et al.
Publicado: (2018)

Oligonucleotide conjugated multi-functional adeno-associated viruses
por: Katrekar, Dhruva, et al.
Publicado: (2018)

Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites
por: Scadden, A. D. J., et al.
Publicado: (2005)

Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing—G/C Substitution Stabilizes GuideRNAs against Editing
por: Heep, Madeleine, et al.
Publicado: (2017)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Promoting RNA editing by ADAR attraction
por: Danan-Gotthold, Miri, et al.
Publicado: (2017)

ADAR RNA editing below the backbone
por: Keegan, Liam, et al.
Publicado: (2017)

Reprogramming, Circular Reasoning and Self versus Non-self: One-Stop Shopping with RNA Editing
por: Savva, Yiannis A., et al.
Publicado: (2016)

Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?
por: Bellingrath, Julia-Sophia, et al.
Publicado: (2023)

A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks
por: Rosani, Umberto, et al.
Publicado: (2019)

ADAR1 Editing and its Role in Cancer
por: Xu, Li-Di, et al.
Publicado: (2018)

ADAR Editing in Viruses: An Evolutionary Force to Reckon with
por: Piontkivska, Helen, et al.
Publicado: (2021)

ADARs act as potent regulators of circular transcriptome in cancer
por: Shen, Haoqing, et al.
Publicado: (2022)

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs
por: Suspène, Rodolphe, et al.
Publicado: (2008)

Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans
por: Schneider, Marius F., et al.
Publicado: (2014)

Predicting sites of ADAR editing in double-stranded RNA
por: Eggington, Julie M., et al.
Publicado: (2011)

The origin of the ADAR gene family and animal RNA editing
por: Grice, Laura F, et al.
Publicado: (2015)

RNA Editing, ADAR1, and the Innate Immune Response
por: Wang, Qingde, et al.
Publicado: (2017)

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
por: Walkley, Carl R., et al.
Publicado: (2017)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs
por: Vitali, Patrice, et al.
Publicado: (2005)

Programmatic introduction of parenchymal cell types into blood vessel organoids
por: Dailamy, Amir, et al.
Publicado: (2021)

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
por: Keegan, Liam P, et al.
Publicado: (2004)

Modulation of ADAR1 editing activity by Z-RNA in vitro
por: Koeris, Michael, et al.
Publicado: (2005)

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR
por: Marcucci, Roberto, et al.
Publicado: (2009)

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
por: Wang, Isabel X., et al.
Publicado: (2013)

Complex regulation of ADAR-mediated RNA-editing across tissues
por: Huntley, Melanie A., et al.
Publicado: (2016)

Novel Engineered Programmable Systems for ADAR-Mediated RNA Editing
por: Aquino-Jarquin, Guillermo
Publicado: (2020)

ADAR1-Mediated RNA Editing and Its Role in Cancer
por: Liu, Jizhe, et al.
Publicado: (2022)

ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts
por: Pecori, Riccardo, et al.
Publicado: (2023)

Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
por: Fischer, Sylvia E. J., et al.
Publicado: (2020)

Identification of evolutionarily meaningful information within the mammalian RNA editing landscape
por: Savva, Yiannis A, et al.
Publicado: (2014)

Editing independent effects of ADARs on the miRNA/siRNA pathways
por: Heale, Bret S E, et al.
Publicado: (2009)

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster
por: Li, Xianghua, et al.
Publicado: (2014)

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins
por: Mannion, Niamh, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_r1p62akf86h02ud6cb09cs8hdr