Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency

Oxidative metabolism in mitochondria regulates cellular differentiation and gene expression through intermediary metabolites and reactive oxygen species. Its role in kidney development and pathogenesis is not completely understood. Here we inactivated ubiquinone-binding protein QPC, a subunit of mit...

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Detalles Bibliográficos
Autores principales: Guan, Nan, Kobayashi, Hanako, Ishii, Ken, Davidoff, Olena, Sha, Feng, Ikizler, Talat A., Hao, Chuan-Ming, Chandel, Navdeep S., Haase, Volker H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232975/
https://www.ncbi.nlm.nih.gov/pubmed/35341793
http://dx.doi.org/10.1016/j.kint.2022.02.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232975/
https://www.ncbi.nlm.nih.gov/pubmed/35341793
http://dx.doi.org/10.1016/j.kint.2022.02.030

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