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The Magic of Linking Rings: Discovery of a Unique Photoinduced Fluorescent Protein Crosslink

[Image: see text] Fluorosubstituted tryptophans serve as valuable probes for fluorescence and nuclear magnetic resonance (NMR) studies of proteins. Here, we describe an unusual photoreactivity introduced by replacing the single tryptophan in cyclophilin A with 7-fluoro-tryptophan. UV exposure at 282...

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Detalles Bibliográficos
Autores principales:	Lu, Manman, Toptygin, Dmitri, Xiang, Yufei, Shi, Yi, Schwieters, Charles D., Lipinski, Emma C., Ahn, Jinwoo, Byeon, In-Ja L., Gronenborn, Angela M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233106/ https://www.ncbi.nlm.nih.gov/pubmed/35574633 http://dx.doi.org/10.1021/jacs.2c02054

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