β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes

Mitochondrial dysfunction plays a central role in type 2 diabetes (T2D); however, the pathogenic mechanisms in pancreatic β-cells are incompletely elucidated. Succinate dehydrogenase (SDH) is a key mitochondrial enzyme with dual functions in the tricarboxylic acid cycle and electron transport chain....

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Detalles Bibliográficos
Autores principales: Lee, Sooyeon, Xu, Haixia, Van Vleck, Aidan, Mawla, Alex M., Li, Albert Mao, Ye, Jiangbin, Huising, Mark O., Annes, Justin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233299/
https://www.ncbi.nlm.nih.gov/pubmed/35472723
http://dx.doi.org/10.2337/db21-0834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233299/
https://www.ncbi.nlm.nih.gov/pubmed/35472723
http://dx.doi.org/10.2337/db21-0834

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