Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation

Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-deficient susceptible populations and the emergence of antifungal drug resistance, there is an urgent need for novel strategies to combat these life-threatening infections. Here, we use a combinatorial screenin...

Descripción completa

Detalles Bibliográficos
Autores principales: Revie, Nicole M., Iyer, Kali R., Maxson, Michelle E., Zhang, Jiabao, Yan, Su, Fernandes, Caroline M., Meyer, Kirsten J., Chen, Xuefei, Skulska, Iwona, Fogal, Meea, Sanchez, Hiram, Hossain, Saif, Li, Sheena, Yashiroda, Yoko, Hirano, Hiroyuki, Yoshida, Minoru, Osada, Hiroyuki, Boone, Charles, Shapiro, Rebecca S., Andes, David R., Wright, Gerard D., Nodwell, Justin R., Del Poeta, Maurizio, Burke, Martin D., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233667/
https://www.ncbi.nlm.nih.gov/pubmed/35752611
http://dx.doi.org/10.1038/s41467-022-31308-1

Ejemplares similares

Ejemplares similares