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The force required to remove tubulin from the microtubule lattice by pulling on its α-tubulin C-terminal tail

Severing enzymes and molecular motors extract tubulin from the walls of microtubules by exerting mechanical force on subunits buried in the lattice. However, how much force is needed to remove tubulin from microtubules is not known, nor is the pathway by which subunits are removed. Using a site-spec...

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Detalles Bibliográficos
Autores principales: Kuo, Yin-Wei, Mahamdeh, Mohammed, Tuna, Yazgan, Howard, Jonathon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233703/
https://www.ncbi.nlm.nih.gov/pubmed/35752623
http://dx.doi.org/10.1038/s41467-022-31069-x