Synthesis and structure–activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2

We previously discovered that triterpenoid saponin platycodin D inhibits the SARS-CoV-2 entry to the host cell. Herein, we synthesized various saponin derivatives and established a structure–activity relationship of saponin-based antiviral agents against SARS-CoV-2. We discovered that the C3-glucose...

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Detalles Bibliográficos
Autores principales: Jang, Youngho, Young Kim, Tai, Jeon, Sangeun, Lim, Hyeonggeun, Lee, JinAh, Kim, Seungtaek, Justin Lee, C., Han, Sunkyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233891/
https://www.ncbi.nlm.nih.gov/pubmed/35809512
http://dx.doi.org/10.1016/j.bioorg.2022.105985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233891/
https://www.ncbi.nlm.nih.gov/pubmed/35809512
http://dx.doi.org/10.1016/j.bioorg.2022.105985

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