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Synthesis and structure–activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2
We previously discovered that triterpenoid saponin platycodin D inhibits the SARS-CoV-2 entry to the host cell. Herein, we synthesized various saponin derivatives and established a structure–activity relationship of saponin-based antiviral agents against SARS-CoV-2. We discovered that the C3-glucose...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233891/ https://www.ncbi.nlm.nih.gov/pubmed/35809512 http://dx.doi.org/10.1016/j.bioorg.2022.105985 |