Structure-based virtual screening for PDL1 dimerizers: Evaluating generic scoring functions

The interaction between PD1 and its ligand PDL1 has been shown to render tumor cells resistant to apoptosis and promote tumor progression. An innovative mechanism to inhibit the PD1/PDL1 interaction is PDL1 dimerization induced by small-molecule PDL1 binders. Structure-based virtual screening is a p...

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Detalles Bibliográficos
Autores principales: Tran-Nguyen, Viet-Khoa, Simeon, Saw, Junaid, Muhammad, Ballester, Pedro J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234010/
https://www.ncbi.nlm.nih.gov/pubmed/35769111
http://dx.doi.org/10.1016/j.crstbi.2022.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234010/
https://www.ncbi.nlm.nih.gov/pubmed/35769111
http://dx.doi.org/10.1016/j.crstbi.2022.06.002

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