Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here we show that BET proteins should not be inactivated therapeutically because...

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Detalles Bibliográficos
Autores principales: Chen, Irene P., Longbotham, James E., McMahon, Sarah, Suryawanshi, Rahul K., Khalid, Mir M., Taha, Taha Y., Tabata, Takako, Hayashi, Jennifer M., Soveg, Frank W., Carlson-Stevermer, Jared, Gupta, Meghna, Zhang, Meng Yao, Lam, Victor L., Li, Yang, Yu, Zanlin, Titus, Erron W., Diallo, Amy, Oki, Jennifer, Holden, Kevin, Krogan, Nevan, Fujimori, Danica Galonić, Ott, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234021/
https://www.ncbi.nlm.nih.gov/pubmed/35839775
http://dx.doi.org/10.1016/j.celrep.2022.111088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234021/
https://www.ncbi.nlm.nih.gov/pubmed/35839775
http://dx.doi.org/10.1016/j.celrep.2022.111088

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