Cargando…

Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression

Background: Paeoniflorin (PF) represents the major bioactive constituent of the traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as a folk medicine in Asian. Paeoniflorin, a bitter pinene monoterpene glycoside, has antidepressant effects, but its pote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Chaofang, Chen, Zhigang, Fan, Lili, Xue, Zhe, Chen, Jianbei, Wang, Xihong, Huang, Zhen, Men, Yinian, Yu, Mingzhi, Liu, Yueyun, Chen, Jiaxu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234202/ https://www.ncbi.nlm.nih.gov/pubmed/35770096 http://dx.doi.org/10.3389/fphar.2022.904190

Ejemplares similares

Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism
por: Lei, Chaofang, et al.
Publicado: (2023)

Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin
por: Yu, Jin-Bo, et al.
Publicado: (2019)

Research progress on classical traditional chinese medicine formula xiaoyaosan in the treatment of depression
por: Chen, Jianbei, et al.
Publicado: (2022)

Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus
por: Jiao, Haiyan, et al.
Publicado: (2021)

Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology
por: Chen, Lisheng, et al.
Publicado: (2021)

Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis
por: Yan, Zhi-Yi, et al.
Publicado: (2021)

Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma
por: Shou, Qiyang, et al.
Publicado: (2019)

The antidepressant-like effects of paeoniflorin in mouse models
por: QIU, FENGMEI, et al.
Publicado: (2013)

Corrigendum: Xiaoyaosan alleviates hippocampal glutamate-induced toxicity in the CUMS rats via NR2B and PI3K/Akt signaling pathway
por: Zhou, Xueming, et al.
Publicado: (2022)

A review for the pharmacological effects of paeoniflorin in the nervous system
por: Hong, Hongxiang, et al.
Publicado: (2022)

Xiaoyaosan Ameliorates Chronic Restraint Stress-Induced Depression-Like Phenotype by Suppressing A2AR Signaling in the Rat Striatum
por: Zhu, Xiaoxu, et al.
Publicado: (2022)

Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression
por: Zhao, Danping, et al.
Publicado: (2022)

The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases
por: Tu, Jiajie, et al.
Publicado: (2019)

Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology
por: Wei, Shizhang, et al.
Publicado: (2020)

UVA Induced Oxidative Stress Was Inhibited by Paeoniflorin/Nrf2 Signaling or PLIN2
por: Lu, Yan-Song, et al.
Publicado: (2020)

Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder
por: Zhang, Sha, et al.
Publicado: (2022)

Protective effects of paeoniflorin on cardiovascular diseases: A pharmacological and mechanistic overview
por: Li, Xiaoya, et al.
Publicado: (2023)

Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions
por: Peng, Li, et al.
Publicado: (2022)

Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination
por: Chen, Yan-Yan, et al.
Publicado: (2022)

The role and mechanism of NLRP3 inflammasome-mediated astrocyte activation in dehydrocorydaline against CUMS-induced depression
por: Fang, Yu, et al.
Publicado: (2022)

The Combination of Aquilaria sinensis (Lour.) Gilg and Aucklandia costus Falc. Volatile Oils Exerts Antidepressant Effects in a CUMS-Induced Rat Model by Regulating the HPA Axis and Levels of Neurotransmitters
por: Li, Huiting, et al.
Publicado: (2021)

Corrigendum: Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions
por: Peng, Li, et al.
Publicado: (2022)

Antidepression and Prokinetic Effects of Paeoniflorin on Rats in the Forced Swimming Test via Polypharmacology
por: Mu, Dao-zhou, et al.
Publicado: (2020)

Deciphering the action mechanism of paeoniflorin in suppressing pancreatic cancer: A network pharmacology study and experimental validation
por: Cao, Chunhao, et al.
Publicado: (2022)

Paeoniflorin Inhibits ASK1-TF Axis by Up-Regulating SOCS3 to Alleviate Radiation Enteritis
por: Sheng, Lei, et al.
Publicado: (2022)

Paeoniflorin and Hydroxysafflor Yellow A in Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction and Inhibit Proinflammatory Cytokine Production
por: Wang, Xin-Tong, et al.
Publicado: (2021)

An Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San
por: Yuan, Naijun, et al.
Publicado: (2020)

Paeoniflorin alleviates liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway
por: Liu, Tong, et al.
Publicado: (2022)

Lactobacillus reuteri strain 8008 attenuated the aggravation of depressive-like behavior induced by CUMS in high-fat diet-fed mice through regulating the gut microbiota
por: Li, Canye, et al.
Publicado: (2023)

Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases—A Mini Review
por: Ma, Xiao, et al.
Publicado: (2020)

Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease
por: Wang, Xian, et al.
Publicado: (2022)

Corrigendum: Lactobacillus reuteri strain 8008 attenuated the aggravation of depressive-like behavior induced by CUMS in high-fat diet-fed mice through regulating the gut microbiota
por: Li, Canye, et al.
Publicado: (2023)

A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice
por: Chen, Jingyu, et al.
Publicado: (2018)

Paeoniflorin Ameliorates Macrophage Infiltration and Activation by Inhibiting the TLR4 Signaling Pathway in Diabetic Nephropathy
por: Shao, Yun-xia, et al.
Publicado: (2019)

Paeoniflorin mitigates high glucose-induced lifespan reduction by inhibiting insulin signaling in Caenorhabditis elegans
por: Liu, Tianwen, et al.
Publicado: (2023)

Paeoniflorin alleviates 17α-ethinylestradiol-induced cholestasis via the farnesoid X receptor-mediated bile acid homeostasis signaling pathway in rats
por: Wang, Rulin, et al.
Publicado: (2022)

Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway
por: Zhou, Xue-Ming, et al.
Publicado: (2021)

Paeoniflorin Resists H(2)O(2)-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway
por: Yuan, Jinping, et al.
Publicado: (2020)

Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?
por: Cui, Meiying, et al.
Publicado: (2021)

High-Throughput and Untargeted Metabolic Profiling Revealed the Potential Effect and Mechanisms of Paeoniflorin in Young Asthmatic Rats
por: Wang, Dan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2hksbuacadbdj2g3fso9tk70dt