The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. The acti...

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Detalles Bibliográficos
Autores principales: Chen, Feng, Wu, Runliu, Liu, Jiao, Kang, Rui, Li, Jinbao, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234224/
https://www.ncbi.nlm.nih.gov/pubmed/35769880
http://dx.doi.org/10.1016/j.isci.2022.104561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234224/
https://www.ncbi.nlm.nih.gov/pubmed/35769880
http://dx.doi.org/10.1016/j.isci.2022.104561

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