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The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that operates by producing metabolite itaconate. Here, we report a key role of STING1 (also known as STING and TMEM173) in mediating ACOD1 expression in myeloid cells in response to toll-like receptor (TLR) signaling. The acti...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234224/ https://www.ncbi.nlm.nih.gov/pubmed/35769880 http://dx.doi.org/10.1016/j.isci.2022.104561 |