Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy

Identifying non-invasive biomarkers is critical to evaluate the long-term safety of adeno-associated virus (AAV)-mediated therapies. Plasma neurofilament light chain (Nf-L) levels are associated with dorsal root ganglia toxicity in rats and monkeys, suggesting that circulating Nf-L is a promising to...

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Detalles Bibliográficos
Autores principales: Farrar, Michelle A., Groen, Ewout, Alves, Christiano R.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234248/
https://www.ncbi.nlm.nih.gov/pubmed/35795776
http://dx.doi.org/10.1016/j.omtm.2022.06.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234248/
https://www.ncbi.nlm.nih.gov/pubmed/35795776
http://dx.doi.org/10.1016/j.omtm.2022.06.005

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