Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy

Identifying non-invasive biomarkers is critical to evaluate the long-term safety of adeno-associated virus (AAV)-mediated therapies. Plasma neurofilament light chain (Nf-L) levels are associated with dorsal root ganglia toxicity in rats and monkeys, suggesting that circulating Nf-L is a promising to...

Descripción completa

Detalles Bibliográficos
Autores principales: Farrar, Michelle A., Groen, Ewout, Alves, Christiano R.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234248/
https://www.ncbi.nlm.nih.gov/pubmed/35795776
http://dx.doi.org/10.1016/j.omtm.2022.06.005
_version_ 1784736025620250624
author Farrar, Michelle A.
Groen, Ewout
Alves, Christiano R.R.
author_facet Farrar, Michelle A.
Groen, Ewout
Alves, Christiano R.R.
author_sort Farrar, Michelle A.
collection PubMed
description Identifying non-invasive biomarkers is critical to evaluate the long-term safety of adeno-associated virus (AAV)-mediated therapies. Plasma neurofilament light chain (Nf-L) levels are associated with dorsal root ganglia toxicity in rats and monkeys, suggesting that circulating Nf-L is a promising tool to be included in clinical trials and practice.
format Online
Article
Text
id pubmed-9234248
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society of Gene & Cell Therapy
record_format MEDLINE/PubMed
spelling pubmed-92342482022-07-05 Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy Farrar, Michelle A. Groen, Ewout Alves, Christiano R.R. Mol Ther Methods Clin Dev Commentary Identifying non-invasive biomarkers is critical to evaluate the long-term safety of adeno-associated virus (AAV)-mediated therapies. Plasma neurofilament light chain (Nf-L) levels are associated with dorsal root ganglia toxicity in rats and monkeys, suggesting that circulating Nf-L is a promising tool to be included in clinical trials and practice. American Society of Gene & Cell Therapy 2022-06-20 /pmc/articles/PMC9234248/ /pubmed/35795776 http://dx.doi.org/10.1016/j.omtm.2022.06.005 Text en Crown Copyright © 2022. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Farrar, Michelle A.
Groen, Ewout
Alves, Christiano R.R.
Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
title Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
title_full Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
title_fullStr Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
title_full_unstemmed Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
title_short Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
title_sort circulating neurofilaments to track dorsal root ganglion toxicity risks with aav-mediated gene therapy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234248/
https://www.ncbi.nlm.nih.gov/pubmed/35795776
http://dx.doi.org/10.1016/j.omtm.2022.06.005
work_keys_str_mv AT farrarmichellea circulatingneurofilamentstotrackdorsalrootgangliontoxicityriskswithaavmediatedgenetherapy
AT groenewout circulatingneurofilamentstotrackdorsalrootgangliontoxicityriskswithaavmediatedgenetherapy
AT alveschristianorr circulatingneurofilamentstotrackdorsalrootgangliontoxicityriskswithaavmediatedgenetherapy

Ejemplares similares