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Circulating neurofilaments to track dorsal root ganglion toxicity risks with AAV-mediated gene therapy
Identifying non-invasive biomarkers is critical to evaluate the long-term safety of adeno-associated virus (AAV)-mediated therapies. Plasma neurofilament light chain (Nf-L) levels are associated with dorsal root ganglia toxicity in rats and monkeys, suggesting that circulating Nf-L is a promising to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234248/ https://www.ncbi.nlm.nih.gov/pubmed/35795776 http://dx.doi.org/10.1016/j.omtm.2022.06.005 |